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RR-11a analog

CAS No. 685543-66-2

RR-11a analog( aza-peptide Michael acceptor, 7a )

Catalog No. M26423 CAS No. 685543-66-2

RR-11a analog is a potent and selective asparaginyl endopeptidases (AE) (Legumain) inhibitors(IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RR-11a analog
  • Note
    Research use only, not for human use.
  • Brief Description
    RR-11a analog is a potent and selective asparaginyl endopeptidases (AE) (Legumain) inhibitors(IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively).
  • Description
    RR-11a analog is a potent and selective asparaginyl endopeptidases (AE) (Legumain) inhibitors(IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively).(In Vivo):RR-11a analog shows a t1/2 of 3-10 min.
  • In Vitro
    ——
  • In Vivo
    RR-11a analog has a half-live of 3-10 min.
  • Synonyms
    aza-peptide Michael acceptor, 7a
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Ligands for Target Protein for PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    685543-66-2
  • Formula Weight
    491.501
  • Molecular Formula
    C22H29N5O8
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (254.33 mM)
  • SMILES
    CCOC(=O)\C=C\C(=O)N(CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80.
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